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Not applicable.

Conceived and designed the study, analyzed the data and wrote the paper: XJD; Performed the experiments: XJZ; The study supervision: QHZ. All authors read and approved the final manuscript.

This work was supported by the National Natural Science Foundation of China (81872236, 81772312 and 81702173), Shanghai Municipal Commission of Health and Family Planning (201840055 and 2018BR37) and Shanghai Jiading Hospital (kjycz-2018-022). The funder had no role in the study design, data