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8/16 survived with a median OS of 29 months. Finally, combination treatment with RA-IL2 and PD-1 blockade is currently being evaluated in Phase 1 clinical trials, and a recent trial demonstrated promising results in cutaneous melanoma \[[@B49]\]. Given that expression of PD-1 is upregulated in tumors with a high mutational burden \[[@B50]\], this combination treatment may be most effective in those patients with B-cell lymphomas who express PD-1. Whether this therapy can be combined with AIHA-Ig in cutaneous melanoma or even other B-cell lymphomas remains to be determined. In another study in which PD-1 blockade was combined with low-dose cyclophosphamide, it showed promising efficacy in a T-cell lymphoma model \[[@B51]\]. This therapy has not yet been tested in human cutaneous lymphomas, although its effect on T-cell expansion has been studied *in vitro*\[[@B52]\].

The majority of patients with cutaneous B-cell lymphomas are elderly individuals, and B-cell lymphomas may be more common in this age group \[[@B41]\]. The use of RA-IL2 and combination treatment with RA-IL2 and PD-1 blockade will require careful monitoring of patients’ overall condition to determine if the high-dose IL-2 regimen could lead to severe adverse effects. Alternatively, it is also possible to administer high-

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Solid Edge is a powerful 3D CAD/CAM, Engineering and BIM program developed by Siemens PLM Software, a division of Siemens. Solid Edge is the only cross-product 3D CAD/CAM/CAM-BIM program with a full range of 2D and 3D drafting, design, and engineering capabilities.

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Go mobile. Tap a click to your mobile devices, which is ideal for design and work on the go.

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